An ultra-fast scalable RESTful API to query large numbers of VCF datapoints

by Loris Cro for Open Bioinformatics Foundation

To run arbitrarily complex queries against dense datasets such as VCF genomic mutations one must have a proper data model and a sensible approach towards query composability in order to be able to "take shortcuts" even when the DBMS' query planner wouldn't be able to. "Composability" is a sharp edge but with proper tooling one can evade the most common pitfalls while still being able to abstract-away implementation details.